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Avapritinib - GIST |
European Journal of Cancer |
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Avapritinib in unresectable or metastatic PDGFRA D842V-mutant gastrointestinal stromal tumours: Long-term efficacy and safety data from the NAVIGATOR phase I trial
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Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
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PIONEER Part 2: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate Safety and Efficacy of Avapritinib in Indolent Systemic Mastocytosis
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Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
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Perceptions of Patient Disease Burden and Management Approaches of Systemic Mastocytosis (SM) By Healthcare Providers (HCPs): Results from the TouchStone SM Survey
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Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
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Increased Detection of KIT D816V Mutation in Peripheral Blood Samples from Patients with Indolent Systemic Mastocytosis (ISM) in the Phase 2 PIONEER Study Using a High Sensitivity Droplet Digital (dd) PCR Assay Compared with Next Generation Sequencing (NGS)
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Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
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Pure Pathologic Response Is Associated with Improved Overall Survival in Patients with Advanced Systemic Mastocytosis Receiving Avapritinib in the Phase I EXPLORER Study
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Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
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Patient Reported Outcomes Among Systemic Mastocytosis (SM) Patients in Routine Clinical Practice: Results from the TouchStone Survey
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Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
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Results from PIONEER: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent Systemic Mastocytosis
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Avapritinib - GIST |
Connective Tissue Oncology Society (CTOS) Annual Meeting |
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Avapritinib vs. Regorafenib in Patients With Locally Advanced Unresectable or Metastatic Gastrointestinal Stromal Tumor (GIST): Efficacy and Safety Data From Phase 3 VOYAGER Study
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Pralsetinib |
IASLC North America Conference on Lung Cancer |
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Analysis of Resistance Mechanisms to Pralsetinib (BLU-667) in Patients with RET Fusion-Positive Non-Small Cell Lung Cancer (NSCLC) from the ARROW Study
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1600591101 September 20, 2020 |
Pralsetinib |
European Society for Medical Oncology (ESMO) Virtual Congress |
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Results from the registrational phase 1/2 ARROW trial of pralsetinib (BLU-667) in patients with advanced RET mutation-positive medullary thyroid cancer
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Avapritinib - GIST |
European Society for Medical Oncology (ESMO) Virtual Congress |
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Long-term efficacy, tolerability and overall survival in patients with unresectable or metastatic PDGFRA D842V-mutant gastrointestinal stromal tumor treated with avapritinib: NAVIGATOR phase 1 trial update
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Avapritinib - GIST |
European Society for Medical Oncology (ESMO) Virtual Congress |
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Clinical Efficacy Comparison of Avapritinib With Other Tyrosine Kinase Inhibitors (TKIs) in Gastrointestinal Stromal Tumors (GIST) With PDGFRA D842V Mutation: A Retrospective Analysis of Clinical Trial and Real-World Data
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BLU-945 |
European Society for Medical Oncology (ESMO) Virtual Congress |
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BLU-945, a highly potent and selective 4th-generation EGFR TKI for the treatment of EGFR+/T790M/C797S resistant NSCLC
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Avapritinib - GIST |
The Lancet Oncology |
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Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial
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Avapritinib - SM |
Virtual Edition of the 25th European Hematology Association (EHA25) Annual Congress |
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Results from PIONEER: a randomized, double-blind, placebo-controlled, Phase 2 study of avapritinib in patients with indolent systemic mastocytosis (ISM)
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Avapritinib - SM |
Virtual Edition of the 25th European Hematology Association (EHA25) Annual Congress |
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Avapritinib induces responses in patients with advanced systemic mastocytosis (AdvSM), regardless of prior midostaurin therapy
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Avapritinib - SM |
European Academy of Allergy and Clinical Immunology (EAACI) 2020 Digital Congress |
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Avapritinib reduces cutaneous symptoms and mast cell burden in patients with indolent systemic mastocytosis in the PIONEER study
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Pralsetinib |
American Society of Clinical Oncology (ASCO) Virtual Scientific Program |
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Clinical activity of the RET inhibitor pralsetinib (BLU-667) in patients with RET fusion+ solid tumors
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Pralsetinib |
American Society of Clinical Oncology (ASCO) Virtual Scientific Program |
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AcceleRET Lung: A Phase 3 Study of First-Line Pralsetinib in Patients with RET Fusion+ Advanced/Metastatic Non-Small-Cell Lung Cancer (NSCLC)
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1590739434 May 29, 2020 |
Pralsetinib |
American Society of Clinical Oncology (ASCO) Virtual Scientific Program |
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Registrational Dataset from the Phase 1/2 ARROW Trial of Pralsetinib (BLU-667) in Patients with Advanced RET Fusion+ Non-Small Cell Lung Cancer (NSCLC)
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Avapritinib - SM |
American Academy of Allergy, Asthma & Immunology (AAAAI) Virtual Oral Abstracts, Case Reports and Poster Sessions |
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PIONEER: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis with Symptoms Inadequately Controlled with Standard Therapy
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Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
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PIONEER: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis with Symptoms Inadequately Controlled with Standard Therapy
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1573772438 November 14, 2019 |
Avapritinib - GIST |
Connective Tissue Oncology Society (CTOS) Annual Meeting |
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Clinical Response to Avapritinib by RECIST and Choi Criteria in ≥ 4th Line and PDGFRA Exon 18 Gastrointestinal Stromal Tumors (GIST)
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1573702237 November 14, 2019 |
Avapritinib - GIST |
Connective Tissue Oncology Society (CTOS) Annual Meeting |
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Avapritinib for the Treatment of GIST: Analysis of Efficacy, Safety, and Patient Management Strategies at the Recommended Phase 2 Dose
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1573137683 November 07, 2019 |
Avapritinib - SM |
ISPOR Europe |
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Psychometric Evaluation of the Advanced Systemic Mastocytosis Symptom Assessment Form (AdvSM-SAF) in patients with Advanced Systemic Mastocytosis
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1573137287 November 07, 2019 |
Avapritinib - SM |
ISPOR Europe |
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Psychometric Performance of the Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF)
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1569920764 October 01, 2019 |
Fisogatinib |
Cancer Discovery |
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First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant Fibroblast Growth Factor 19 Signaling as a Driver Event in Hepatocellular Carcinoma
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1569920650 October 01, 2019 |
Fisogatinib |
Cancer Discovery |
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Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma
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Pralsetinib |
European Society for Medical Oncology (ESMO) Annual Meeting |
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Treatment With Pralsetinib (BLU-667), a Potent and Selective RET Inhibitor, Provides Rapid Clearance of ctDNA in Patients With RET-Altered Non-Small Cell Lung Cancer (NSCLC) and Thyroid Cancer
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BLU-782 |
American Society for Bone and Mineral Research (ASMBR) Annual Meeting |
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A clinical update on BLU-782, an investigational selective ALK2 inhibitor in development for fibrodysplasia ossificans progressiva (FOP)
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1568023113 September 09, 2019 |
Pralsetinib |
IASLC World Conference on Lung Cancer |
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Pralsetinib (BLU-667) demonstrates robust activity in RET-fusion-driven intracranial tumor models
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1560579358 June 15, 2019 |
Avapritinib - SM |
European Hematology Association (EHA) Annual Meeting |
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Avapritinib, a Potent and Selective Inhibitor of KIT D816V, Induces Complete and Durable Responses in Patients (pts) with Advanced Systemic Mastocytosis (AdvSM)
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1559552740 June 03, 2019 |
Pralsetinib |
American Society of Clinical Oncology (ASCO) Annual Meeting |
|
Clinical Activity and Tolerability of BLU-667, a Highly Potent and Selective RET Inhibitor, in Patients with Advanced RET-Fusion+ Non-small Cell Lung Cancer
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1559398538 June 01, 2019 |
Pralsetinib |
American Society of Clinical Oncology (ASCO) Annual Meeting |
|
Activity and Tolerability of BLU-667, a Highly Potent and Selective RET Inhibitor, in Patients with Advanced RET-altered Thyroid Cancers
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1559379949 June 01, 2019 |
Avapritinib - GIST |
American Society of Clinical Oncology (ASCO) Annual Meeting |
|
Clinical Activity of Avapritinib in ≥4th Line (4L+) and PDGFRA Exon 18 Gastrointestinal Stromal Tumors (GIST)
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1553970136 March 30, 2019 |
Pralsetinib |
American Association for Cancer Research (AACR) Annual Meeting |
|
Discovery of BLU-667 for RET-driven cancers
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1543789289 December 02, 2018 |
Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
|
Avapritinib, a Potent and Selective Inhibitor of KIT D816V, Improves Symptoms of Advanced Systemic Mastocytosis (AdvSM) (oral presentation)
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1542320453 November 15, 2018 |
Avapritinib - GIST |
Connective Tissue Oncology Society (CTOS) Annual Meeting |
|
Avapritinib is Highly Active and Well-tolerated in Patients With Advanced GIST Driven by a Diverse Variety of Oncogenic Mutations in KIT and PDGFRA (oral presentation)
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1540246817 October 22, 2018 |
Avapritinib - GIST |
European Society for Medical Oncology (ESMO) Annual Meeting |
|
Correlation of ctDNA and Response in Patients with PDGFRα D842 GIST Treated with Avapritinib (poster presentation)
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1540246775 October 22, 2018 |
Avapritinib - GIST |
European Society for Medical Oncology (ESMO) Annual Meeting |
|
An Open-label, Randomized, Phase 3 Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Metastatic or Unresectable Gastrointestinal Stromal Tumor (poster presentation)
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1538864323 October 06, 2018 |
Pralsetinib |
American Thyroid Association (ATA) Annual Meeting |
|
Clinical activity of BLU-667, a highly selective RET inhibitor, in advanced RET-altered thyroid cancers: updated results from the phase 1 ARROW study (oral presentation)
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1538432296 October 01, 2018 |
Avapritinib - GIST |
Clinical Cancer Research |
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Robust activity of avapritinib, potent and highly selective inhibitor of mutated KIT, in patient-derived xenograft models of gastrointestinal stromal tumors
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1538345823 September 30, 2018 |
BLU-782 |
American Society for Bone and Mineral Research (ASBMR) Annual Meeting |
|
BLU-782: A highly selective ALK2 inhibitor, designed specifically to target the cause of fibrodysplasia ossificans progressiva
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1538000121 September 26, 2018 |
Pralsetinib |
IASLC World Conference on Lung Cancer |
|
Activity of osimertinib and the selective RET inhibitor BLU-667 in an EGFR-mutant patient with acquired RET rearrangement (oral presentation)
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1538000089 September 26, 2018 |
Pralsetinib |
Cancer Discovery |
|
Landscape of acquired resistance to osimertinib in EGFR-mutant NSCLC and clinical validation of combined EGFR and RET inhibition with osimertinib and BLU-667 for acquired RET fusion
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1529100833 June 15, 2018 |
Avapritinib - SM |
European Hematology Association (EHA) Annual Meeting |
|
Avapritinib (BLU-285), a Selective KIT Inhibitor, is Associated with High Response Rate and Tolerable Safety Profile in Advanced Systemic Mastocytosis: Results of a Phase 1 Study (poster presentation)
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1523830394 April 15, 2018 |
Pralsetinib |
American Association for Cancer Research (AACR) Annual Meeting |
|
Highly potent and selective RET inhibitor, BLU-667, achieves proof of concept in ARROW, a phase 1 study of advanced, RET-altered solid tumors (oral presentation)
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1523830353 April 15, 2018 |
Pralsetinib |
Cancer Discovery |
|
Precision targeted therapy with BLU-667 for RET-driven cancers
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1512943899 December 10, 2017 |
Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
|
Clinical activity in a Phase 1 study of BLU-285, a potent, highly-selective inhibitor of KIT D816V in advanced systemic mastocytosis (plenary oral presentation)
|
|
|
1510351812 November 10, 2017 |
Avapritinib - GIST |
Connective Tissue Oncology Society (CTOS) Annual Meeting |
|
Clinical activity of BLU-285, a highly potent and selective KIT/PDGFRα inhibitor designed to treat gastrointestinal stromal tumor (GIST) (oral presentation)
|
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1509574157 November 01, 2017 |
Avapritinib |
Science Translational Medicine |
|
A precision therapy against cancers driven by KIT/PDGFRA mutations
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1509314866 October 29, 2017 |
Pralsetinib |
Molecular Targets and Cancer Therapeutics (AACR – NCI – EORTC) |
|
BLU-667 is a Potent and Highly Selective RET Inhibitor Being Developed for RET-Driven Cancers
|
|
|
1505685990 September 17, 2017 |
Fisogatinib |
International Liver Cancer Association (ILCA) Annual Conference |
|
(Clinical activity Of BLU-554, a potent, highly-selective FGFR4 inhibitor in advanced HCC with FGFR4 pathway activation (oral presentation)
|
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1505081139 September 10, 2017 |
Fisogatinib |
European Society for Medical Oncology (ESMO) Annual Meeting |
|
Phase 1 Safety and Clinical Activity of BLU-554 in advanced hepatocellular carcinoma (oral presentation)
|
|
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1501452295 July 30, 2017 |
Pralsetinib |
World Congress on Thyroid Cancer |
|
BLU-667 is a potent and highly selective RET inhibitor in development for RET-driven thyroid cancers
|
|
|
1496700240 June 05, 2017 |
Avapritinib - GIST |
American Society of Clinical Oncology (ASCO) Annual Meeting |
|
Clinical activity of BLU-285 in advanced gastrointestinal stromal tumor (GIST) (oral presentation)
|
|
|
1491170553 April 02, 2017 |
Avapritinib - GIST |
American Association for Cancer Research (AACR) Annual Meeting |
|
BLU-285: A potent and highly selective inhibitor designed to target malignancies driven by KIT and PDGFRα mutations (oral presentation)
|
|
|
1491170447 April 02, 2017 |
Avapritinib - SM |
American Association for Cancer Research (AACR) Annual Meeting |
|
BLU-285: A potent and highly selective inhibitor designed to target malignancies driven by KIT and PDGFRα mutations (oral presentation)
|
|
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1480888795 December 04, 2016 |
Avapritinib - SM |
American Society of Hematology (ASH) Annual Meeting |
|
Preliminary Safety and Activity in a Phase 1 study of BLU-285, a Potent, Highly-Selective Inhibitor of KIT D816V in Advanced Systemic Mastocytosis (SM) (oral presentation)
|
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1480629552 December 01, 2016 |
Avapritinib - GIST |
EORTC – NCI – AACR Molecular Targets and Cancer Therapeutics Symposium |
|
Preliminary safety and activity in a first-in-human Phase 1 study of BLU-285, a potent, highly selective inhibitor of KIT and PDGFRα activation loop mutants in advanced gastrointestinal stromal tumor (GIST) (oral presentation)
|
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1480456639 November 29, 2016 |
Fisogatinib |
Molecular Targets and Cancer Therapeutics (EORTC – NCI – AACR) |
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First-in-human study of BLU-554, a potent, highly selective FGFR4 inhibitor designed for hepatocellular carcinoma (HCC) with FGFR4 pathway activation (poster presentation)
|
|
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1461016563 April 18, 2016 |
Pralsetinib |
American Association for Cancer Research (AACR) Annual Meeting |
|
The development of Potent and Selective RET inhibitors
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1430516121 May 01, 2015 |
Research |
Journal of Clinical Investigation |
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Targeting cancer with kinase inhibitors
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1426541525 March 16, 2015 |
Fisogatinib |
Cancer Discovery |
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First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway
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1411162202 September 19, 2014 |
Research |
Nature Communications |
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Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes
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Research |
Nature Communications |
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The landscape of kinase fusions in cancer
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