Getting medicines to those who need them most

We recognize that the patients and families affected by life-threatening diseases anxiously await more effective medicines with each passing day. Knowing this drives us to work harder to deliver transformative treatments more swiftly.

We also seek to ensure any medicine we develop is safe and effective and follows the rigorous guidelines established by regulatory agencies.

We strive to balance these two complementary and vital goals in all that we do.

Our clinical trials

Our clinical trials in

Systemic mastocytosis (SM)

Trial Phase

Trial Phase 2

Target Population

Target Population

Aggressive SM, SM with associated hematologic neoplasm and mast cell leukemia

Study Status

Study Status

Active, fully enrolled

ClinicalTrials.gov
Study Number

Study Number

NCT03580655

Trial Phase

Trial Phase 2

Target Population

Target Population

Indolent SM

Study Status

Study Status

Active, fully enrolled

ClinicalTrials.gov
Study Number

Study Number

NCT03731260

Trial Phase

BP_Web_3.0_Trial_2-3

Target Population

Target Population

Indolent SM

Study Status

Study Status

Active, recruiting

ClinicalTrials.gov
Study Number

Study Number

NCT04910685

Trial Phase

Trial Phase 1/2

Target Population

Target Population

Aggressive SM, SM with associated hematologic neoplasm, mast cell leukemia and other KIT-altered hematological malignancies

Study Status

Not yet recruiting

ClinicalTrials.gov
Study Number

Study Number

NCT05609942

Our clinical trials in

RET-altered cancers

Trial Phase

Trial Phase 1/2

Target Population

Target Population

RET-altered non-small cell lung cancer (NSCLC), thyroid cancer (TC) or other solid tumors with a RET fusion or mutation

Study Status

Study Status

Active, fully enrolled

ClinicalTrials.gov
Study Number

Study Number

NCT03037385

Trial Phase

Trial Phase 3

Target Population

Target Population

First-line RET fusion-positive, metastatic NSCLC

Study Status

Study Status

Active, recruiting

ClinicalTrials.gov
Study Number

Study Number

NCT04222972

Our clinical trials in

EGFR-mutated non-small cell lung cancer (NSCLC)

Trial Phase

Trial Phase 1/2

Target Population

Target Population

Treatment-resistant EGFR-mutated NSCLC

Study Status

Study Status

Active, recruiting

ClinicalTrials.gov
Study Number

Study Number

NCT04862780

Trial Phase

Trial Phase 1/2

Target Population

Target Population

NSCLC and other cancers with EGFR exon 20 insertion mutations

Study Status

Study Status

Active, recruiting

ClinicalTrials.gov
Study Number

Study Number

NCT05241873

Our clinical trials in

CDK2-vulnerable cancers and estrogen receptor-positive (ER+), HER2-negative (HER2-) breast cancer

Trial Phase

Trial Phase 1

Target Population

Target Population

Cyclin E aberrant ovarian cancer, endometrial cancer, gastric cancer and other solid tumors, and ER+, HER2- breast cancer

Study Status

Study Status

Active, recruiting

ClinicalTrials.gov
Study Number

Study Number

NCT05252416

Our clinical trials in

Pediatric cancers

Trial Phase

Trial Phase 1/2

Target Population

Target Population

Solid tumors with a KIT or PDGFRA mutation and gliomas with an H3K27M mutation in pediatric patients

Study Status

Study Status

Active, recruiting

ClinicalTrials.gov
Study Number

Study Number

NCT04773782