Blueprint Medicines’ Compliance and Ethics Program

Integrity is fundamental to everything we do at Blueprint Medicines. We have established a Comprehensive Compliance Program (“Program”) to set the standards for how we conduct business with integrity, and to communicate to all Blueprint personnel, agents and contractors acting on Blueprint Medicines’ behalf our expectations to operate in accordance with ethical business practices and our Core Values: Patients First, Thoughtfulness, Urgency, Trust and Optimism.

Our program is based on the seven elements of an effective compliance program as outlined in the Compliance Program Guidance for Pharmaceutical Manufacturers issued in 2003 by the Office of the Inspector General of the Department of Health and Human Services. Blueprint Medicines has adopted the Pharmaceutical Research and Manufacturers of America Code and has implemented policies and procedures that are consistent with its requirements. We assess our Program periodically to meet evolving compliance needs as well as additional laws and guidance.