Blueprint Medicines has developed a powerful target discovery engine to provide new insights into the biology of kinases as drivers of cancer and other debilitating diseases and to identify new and promising kinase drug targets.
There are two aspects to our novel target discovery engine:
- Genomics approach. Our high-capacity computing infrastructure enables not only storage of very large genomic databases but also rapid analyses of these data using our proprietary algorithms to analyze human tumor sequences.
- Cell-based Screens. We use a subset of compounds in our library that exhibit remarkable potency and selectivity for particular kinases as probes in disease-relevant, cell-based screens. Many of these compounds inhibit kinases of unknown biology, allowing us to evaluate the role of these relatively unexplored kinases in human disease.